N3-C2-NHS ester

Research use only, not for human use.

N3-C2-NHS ester (3-Azidopropanoic acid NHS ester) is an ADC linker, which is a cross-linking agent for macromolecular compounds, and can be used for the synthesis of antibody-coupled reactive molecules (ADCs).

N3-C2-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-C2-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Antibody Drug Conjugates (ADC)

ADCs Linker/Click Chemistry

ADC Linker

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850180-76-6

212.16

C7H8N4O4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (471.34 mM; Ultrasonic )

[N-]=[N+]=NCCC(=O)ON1C(=O)CCC1=O

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(-20℃)

With Ice Pack

≥ 2 years